[6] Club America 3-1 Santos Laguna [16] 2016-10-30 02:00
Vejr: Gode Stadium: Azteca Bane: Gode Round: 15
Referee: Jorge Antonio Perez Duran Home Manager: Ricardo La Volpe Away Manager: Jose Manuel De la Torre
Head to Head
| CONCACAF Champions Cup | 2016/04/06 02:00 | Club America v Santos Laguna | W | 1-0 |
| CONCACAF Champions Cup | 2016/03/17 02:00 | Santos Laguna v Club America | D | 0-0 |
| Mexico - Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | W | 2-0 |
| Mexico - Liga MX | 2015/08/15 02:30 | Santos Laguna v Club America | W | 0-2 |
| Mexico - Liga MX | 2015/03/14 23:00 | Club America v Santos Laguna | W | 1-0 |
| Mexico - Liga MX | 2014/09/27 02:30 | Santos Laguna v Club America | W | 1-4 |
| Mexico - Liga MX | 2014/05/04 02:00 | Santos Laguna v Club America | L | 3-1 |
| Mexico - Liga MX | 2014/05/01 01:00 | Club America v Santos Laguna | W | 5-3 |