Stadium: Red Bull Arena Round: 1
Home Manager: Robert Prunty Away Manager: Hue Jackson
| NCAAF | 2022/11/26 19:00 | Grambling State v Southern | L | 17-34 |
| NCAAF | 2022/11/13 00:00 | Grambling State v Texas Southern Tigers | L | 7-41 |
| NCAAF | 2022/11/05 19:00 | Arkansas Pine Bluff v Grambling State | W | 10-36 |
| NCAAF | 2022/10/29 19:00 | Alcorn State v Grambling State | W | 6-35 |
| NCAAF | 2022/10/15 18:00 | Florida A&M v Grambling State | L | 20-16 |
| NCAAF | 2022/10/08 18:00 | Grambling State v Alabama | L | 31-37 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | L | 34-14 |
| NCAAF | 2022/09/24 18:00 | Grambling State v Bethune Cookman | L | 19-36 |
| NCAAF | 2022/11/19 18:00 | Hampton v Towson | L | 7-27 |
| NCAAF | 2022/11/12 18:00 | Elon v Hampton | L | 38-24 |
| NCAAF | 2022/11/05 17:00 | William & Mary v Hampton | L | 20-14 |
| NCAAF | 2022/10/29 17:00 | Hampton v Villanova | L | 10-24 |
| NCAAF | 2022/10/22 18:00 | Richmond v Hampton | L | 41-10 |
| NCAAF | 2022/10/15 19:30 | Hampton v Albany | W | 38-37 |
| NCAAF | 2022/10/08 18:00 | Maine v Hampton | L | 31-24 |
| NCAAF | 2022/09/24 22:00 | Hampton v Delaware | L | 3-35 |