Stadium: Roy Stewart Stadium Round: 1
Home Manager: Dean Hood Away Manager: Steve Englehart
| NCAAF | 2022/11/19 18:00 | Presbyterian v Stetson Hatters | L | 21-42 |
| NCAAF | 2022/11/05 17:00 | Dayton v Presbyterian | L | 52-28 |
| NCAAF | 2022/10/29 16:00 | Presbyterian v Marist | L | 7-37 |
| NCAAF | 2022/10/22 17:00 | St.Thomas MIN v Presbyterian | L | 46-17 |
| NCAAF | 2022/10/15 21:00 | Presbyterian v San Diego | L | 3-28 |
| NCAAF | 2022/10/08 16:00 | Valparaiso v Presbyterian | L | 41-21 |
| NCAAF | 2022/10/01 17:00 | Presbyterian v Morehead State | L | 10-14 |
| NCAAF | 2022/09/24 23:00 | Davidson Wildcats v Presbyterian | L | 56-24 |
| NCAAF | 2022/11/19 19:00 | Murray State v SE Missouri St | L | 22-52 |
| NCAAF | 2022/11/12 19:00 | Robert Morris v Murray State | W | 9-27 |
| NCAAF | 2022/10/29 19:00 | Tennessee State v Murray State | W | 3-19 |
| NCAAF | 2022/10/22 18:00 | Murray State v Lindenwood | L | 18-33 |
| NCAAF | 2022/10/15 20:00 | Murray State v Austin Peay | L | 17-52 |
| NCAAF | 2022/10/08 19:00 | Tennessee Martin v Murray State | L | 45-16 |
| NCAAF | 2022/10/01 23:00 | Murray State v SE Louisiana | L | 14-48 |
| NCAAF | 2022/09/24 21:00 | Eastern Illinois v Murray State | L | 35-21 |