[12] Michigan State 7-29 Michigan [3] 2022-10-29 23:30
Stadium: Michigan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Melvin Tucker
Head to Head
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | W | 33-37 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | W | 27-24 |
| NCAAF | 2019/11/16 17:00 | Michigan State v Michigan | L | 10-44 |
| NCAAF | 2018/10/20 16:00 | Michigan v Michigan State | L | 21-7 |
| NCAAF | 2017/10/07 23:30 | Michigan State v Michigan | W | 14-10 |
| NCAAF | 2016/10/29 16:00 | Michigan v Michigan State | L | 32-23 |
| NCAAF | 2015/10/17 19:30 | Michigan v Michigan State | W | 23-27 |
| NCAAF | 2014/10/25 19:30 | Michigan State v Michigan | W | 35-11 |
Home History
| NCAAF | 2022/10/15 20:00 | Wisconsin v Michigan State | W | 28-34 |
| NCAAF | 2022/10/08 20:00 | Ohio State v Michigan State | L | 49-20 |
| NCAAF | 2022/10/01 19:30 | Michigan State v Maryland | L | 13-27 |
| NCAAF | 2022/09/24 19:30 | Minnesota v Michigan State | L | 34-7 |
| NCAAF | 2022/09/17 23:30 | Michigan State v Washington | L | 28-39 |
| NCAAF | 2022/09/10 20:00 | Akron v Michigan State | W | 0-52 |
| NCAAF | 2022/09/02 23:00 | Western Michigan v Michigan State | W | 13-35 |
| NCAAF Bowl Games | 2021/12/31 00:00 | Pittsburgh v Michigan State | W | 21-31 |
Away History
| NCAAF | 2022/10/15 16:00 | Penn State v Michigan | W | 17-41 |
| NCAAF | 2022/10/08 16:00 | Michigan v Indiana | W | 31-10 |
| NCAAF | 2022/10/01 16:00 | Michigan v Iowa | W | 27-14 |
| NCAAF | 2022/09/24 16:00 | Maryland v Michigan | W | 27-34 |
| NCAAF | 2022/09/17 16:00 | Connecticut v Michigan | W | 0-59 |
| NCAAF | 2022/09/11 00:00 | Hawaii v Michigan | W | 10-56 |
| NCAAF | 2022/09/03 16:00 | Colorado State v Michigan | W | 7-51 |
| NCAAF | 2022/01/01 00:30 | Georgia v Michigan | L | 34-11 |