Stadium: Gate City Bank Field at the Fargodome Round: 1
Home Manager: Matt Entz Away Manager: Todd Stepsis
| NCAAF | 2021/11/20 18:00 | Drake Bulldogs v Davidson Wildcats | L | 14-45 |
| NCAAF | 2021/11/13 18:00 | St.Thomas MIN v Drake Bulldogs | L | 21-14 |
| NCAAF | 2021/11/06 16:00 | Drake Bulldogs v Marist | L | 0-7 |
| NCAAF | 2021/10/16 21:00 | Drake Bulldogs v San Diego | L | 10-13 |
| NCAAF | 2021/10/09 17:00 | Dayton v Drake Bulldogs | L | 28-10 |
| NCAAF | 2021/10/02 16:00 | Drake Bulldogs v Butler | W | 6-3 |
| NCAAF | 2021/09/25 17:00 | Valparaiso v Drake Bulldogs | L | 24-21 |
| NCAAF | 2021/09/18 21:00 | Drake Bulldogs v North Dakota | L | 0-38 |
| NCAAF | 2022/01/08 17:00 | Montana State v North Dakota State | W | 10-38 |
| NCAAF | 2021/12/18 02:15 | James Madison v North Dakota State | W | 14-20 |
| NCAAF | 2021/12/11 17:00 | East Tennessee State v North Dakota State | W | 3-27 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | W | 7-38 |
| NCAAF | 2021/11/20 20:30 | South Dakota v North Dakota State | W | 24-52 |
| NCAAF | 2021/11/13 17:00 | North Dakota State v Youngstown State | W | 49-17 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | L | 19-27 |
| NCAAF | 2021/10/30 19:30 | Indiana State v North Dakota State | W | 2-44 |