[18] Reilly Opelka 6-3,7-6 John Isner [27] 2022-04-10 19:00
Stadium: Stadium Court Round: 29 Ground: Clay
Head to Head
| ATP - Dallas | 2022/02/12 22:00 | John Isner v Reilly Opelka | 6-7,6-7 |
| ATP - Atlanta | 2019/07/24 23:00 | John Isner v Reilly Opelka | 6-7,7-6,6-7 |
| ATP - New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
Home History
| ATP - Houston | 2022/04/09 18:00 | Nick Kyrgios v Reilly Opelka | 3-6,5-7 |
| ATP - Houston | 2022/04/08 17:00 | Reilly Opelka v Gijs Brouwer | 6-3,7-5 |
| ATP - Houston | 2022/04/06 23:00 | Reilly Opelka v Mitchell Krueger | 3-6,6-2,6-4 |
| ATP - Indian Wells | 2022/03/16 20:45 | Rafael Nadal v Reilly Opelka | 7-6,7-6 |
| ATP - Indian Wells | 2022/03/14 22:30 | Reilly Opelka v Denis Shapovalov | 6-7,6-4,6-4 |
| ATP - Indian Wells | 2022/03/12 20:50 | Reilly Opelka v Lorenzo Musetti | 6-1,6-4 |
| ATP - Delray Beach | 2022/02/20 20:00 | Cameron Norrie v Reilly Opelka | 7-6,7-6 |
| ATP - Delray Beach | 2022/02/20 01:00 | John Millman v Reilly Opelka | 6-7,7-6,6-7 |
Away History
| ATP - Houston | 2022/04/09 19:30 | John Isner v Cristian Garin | 4-6,6-3,6-4 |
| ATP - Houston | 2022/04/08 23:00 | Frances Tiafoe v John Isner | 4-6,6-2,3-6 |
| ATP - Houston | 2022/04/08 01:55 | Steve Johnson v John Isner | 7-6,6-7,3-6 |
| ATP - Miami | 2022/03/25 18:05 | John Isner v Hugo Gaston | 6-7,4-6 |
| ATP - Indian Wells | 2022/03/16 21:30 | John Isner v Grigor Dimitrov | 3-6,6-7 |
| ATP - Indian Wells | 2022/03/15 22:05 | Diego Schwartzman v John Isner | 5-7,3-6 |
| ATP - Indian Wells | 2022/03/13 18:00 | Sam Querrey v John Isner | 6-7,6-7 |
| ATP - Acapulco | 2022/02/24 00:00 | Cameron Norrie v John Isner | 6-7,6-3,6-4 |