Stadium: F. G. Clark Center
Home Manager: Sean Woods Away Manager: Reggie Theus
| USA - NCAAB | 2022/01/11 00:30 | Southern v Bethune Cookman | L | 69-59 |
| USA - NCAAB | 2022/02/22 02:00 | Alabama State v Bethune Cookman | L | 89-78 |
| USA - NCAAB | 2022/02/19 21:00 | Alabama A&M v Bethune Cookman | L | 62-60 |
| USA - NCAAB | 2022/02/15 01:30 | Bethune Cookman v Jackson State | L | 51-71 |
| USA - NCAAB | 2022/02/12 21:00 | Bethune Cookman v Alcorn State | W | 71-63 |
| USA - NCAAB | 2022/02/08 00:30 | Texas Southern v Bethune Cookman | L | 66-63 |
| USA - NCAAB | 2022/02/05 20:00 | Prairie View v Bethune Cookman | W | 67-68 |
| USA - NCAAB | 2022/01/31 23:00 | Bethune Cookman v Alabama A&M | L | 52-67 |
| USA - NCAAB | 2022/01/29 08:27 | Bethune Cookman v Alabama State | L | 73-79 |
| USA - NCAAB | 2022/02/19 22:30 | Grambling State v Southern | L | 61-57 |
| USA - NCAAB | 2022/02/15 01:30 | Southern v Texas Southern | W | 70-58 |
| USA - NCAAB | 2022/02/12 23:30 | Southern v Prairie View | L | 77-84 |
| USA - NCAAB | 2022/02/08 01:30 | Alabama State v Southern | W | 58-72 |
| USA - NCAAB | 2022/02/05 23:15 | Alabama A&M v Southern | W | 64-73 |
| USA - NCAAB | 2022/02/01 01:30 | Southern v Jackson State | W | 75-64 |
| USA - NCAAB | 2022/01/29 21:00 | Southern v Alcorn State | L | 64-68 |
| USA - NCAAB | 2022/01/24 08:27 | Mississippi Valley State v Southern | W | 72-100 |