[4] NY Rangers 2-1 BUF Sabres [13] 2021-12-11 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Gerard Gallant
Head to Head
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | W | 4-5 |
| NHL | 2021/04/27 23:00 | BUF Sabres v NY Rangers | W | 1-3 |
| NHL | 2021/04/25 22:00 | BUF Sabres v NY Rangers | W | 3-6 |
| NHL | 2021/04/03 23:00 | NY Rangers v BUF Sabres | L | 2-3 |
| NHL | 2021/04/01 23:00 | NY Rangers v BUF Sabres | W | 3-2 |
| NHL | 2021/03/22 23:00 | BUF Sabres v NY Rangers | W | 3-5 |
| NHL | 2021/03/03 00:00 | BUF Sabres v NY Rangers | W | 2-3 |
| NHL | 2021/01/29 00:00 | NY Rangers v BUF Sabres | W | 3-2 |
Home History
| NHL | 2021/12/09 00:00 | COL Avalanche v NY Rangers | L | 7-3 |
| NHL | 2021/12/08 01:30 | NY Rangers v CHI Blackhawks | W | 6-2 |
| NHL | 2021/12/05 01:00 | CHI Blackhawks v NY Rangers | W | 2-3 |
| NHL | 2021/12/04 00:00 | SJ Sharks v NY Rangers | W | 0-1 |
| NHL | 2021/12/02 00:00 | PHI Flyers v NY Rangers | W | 1-4 |
| NHL | 2021/11/26 18:00 | NY Rangers v BOS Bruins | W | 5-2 |
| NHL | 2021/11/25 00:30 | NY Rangers v NY Islanders | W | 4-1 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | W | 4-5 |
Away History
| NHL | 2021/12/08 00:30 | ANA Ducks v BUF Sabres | L | 2-0 |
| NHL | 2021/12/05 00:30 | BUF Sabres v CAR Hurricanes | L | 2-6 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2021/11/30 00:00 | SEA Kraken v BUF Sabres | L | 7-4 |
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | L | 2-3 |
| NHL | 2021/11/27 00:00 | MON Canadiens v BUF Sabres | W | 1-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |