[6] BUF Sabres 2-6 CAR Hurricanes [5] 2021-12-05 00:30
Stadium: PNC Arena
Home Manager: Rod Brind'Amour Away Manager: Don Granato
Head to Head
| NHL | 2019/11/15 00:00 | CAR Hurricanes v BUF Sabres | L | 5-4 |
| NHL | 2019/03/16 23:00 | BUF Sabres v CAR Hurricanes | L | 2-4 |
| NHL | 2019/02/08 00:00 | CAR Hurricanes v BUF Sabres | L | 6-5 |
| NHL | 2019/01/12 00:30 | BUF Sabres v CAR Hurricanes | L | 3-4 |
| NHL | 2017/12/24 00:00 | BUF Sabres v CAR Hurricanes | L | 2-4 |
| NHL | 2017/12/16 00:00 | CAR Hurricanes v BUF Sabres | L | 5-4 |
| NHL | 2017/11/19 00:00 | CAR Hurricanes v BUF Sabres | L | 3-1 |
| NHL - Pre-Season | 2017/09/18 23:00 | CAR Hurricanes v BUF Sabres | L | 3-2 |
Home History
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | L | 4-7 |
| NHL | 2021/11/30 00:00 | SEA Kraken v BUF Sabres | L | 7-4 |
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | L | 2-3 |
| NHL | 2021/11/27 00:00 | MON Canadiens v BUF Sabres | W | 1-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
Away History
| NHL | 2021/12/03 00:00 | OTT Senators v CAR Hurricanes | L | 3-2 |
| NHL | 2021/12/01 01:30 | CAR Hurricanes v DAL Stars | L | 1-4 |
| NHL | 2021/11/28 18:00 | WAS Capitals v CAR Hurricanes | L | 4-2 |
| NHL | 2021/11/26 20:30 | CAR Hurricanes v PHI Flyers | W | 6-3 |
| NHL | 2021/11/25 03:00 | CAR Hurricanes v SEA Kraken | L | 1-2 |
| NHL | 2021/11/23 03:30 | CAR Hurricanes v SJ Sharks | L | 1-2 |
| NHL | 2021/11/20 21:00 | CAR Hurricanes v LA Kings | W | 5-4 |
| NHL | 2021/11/19 03:00 | CAR Hurricanes v ANA Ducks | W | 2-1 |