Stadium: Walter J. Zable Stadium at Cary Field Round: 1
Home Manager: Mike London Away Manager: Curt Cignetti
| NCAAF | 2021/03/27 17:00 | James Madison v William & Mary | W | 38-10 |
| NCAAF | 2019/10/19 19:30 | James Madison v William & Mary | W | 38-10 |
| NCAAF | 2018/09/22 19:30 | William & Mary v James Madison | W | 0-51 |
| NCAAF | 2017/10/21 19:30 | William & Mary v James Madison | W | 14-46 |
| NCAAF | 2021/11/06 19:30 | Campbell v James Madison | W | 14-51 |
| NCAAF | 2021/10/30 18:00 | Elon v James Madison | W | 21-45 |
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | W | 22-10 |
| NCAAF | 2021/10/16 18:00 | James Madison v Richmond | W | 19-3 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | L | 28-27 |
| NCAAF | 2021/10/02 19:30 | James Madison v New Hampshire | W | 23-21 |
| NCAAF | 2021/09/19 00:00 | James Madison v Weber State | W | 37-24 |
| NCAAF | 2021/09/11 20:00 | Maine v James Madison | W | 7-55 |
| NCAAF | 2021/11/06 17:00 | William & Mary v Delaware | L | 3-24 |
| NCAAF | 2021/10/30 17:00 | William & Mary v Villanova | W | 31-18 |
| NCAAF | 2021/10/23 19:30 | Towson v William & Mary | W | 14-40 |
| NCAAF | 2021/10/16 16:00 | William & Mary v Maine | L | 16-27 |
| NCAAF | 2021/10/09 19:30 | Albany v William & Mary | W | 24-31 |
| NCAAF | 2021/09/25 18:00 | William & Mary v Elon | W | 34-31 |
| NCAAF | 2021/09/18 17:00 | William & Mary v Colgate | W | 27-7 |
| NCAAF | 2021/09/11 22:00 | Lafayette v William & Mary | W | 3-24 |