[1] Bayer Leverkusen 4-0 Real Betis [2] 2021-11-04 20:00
Stadium: BayArena Round: 4
Referee: Anthony Taylor Home Manager: Gerardo Seoane Away Manager: Manuel Pellegrini
Head to Head
| UEFA Europa League | 2021/10/21 16:45 | Real Betis v Bayer Leverkusen | D | 1-1 |
Home History
| Tyskland - Bundesliga | 2021/10/30 13:30 | Bayer Leverkusen v Wolfsburg | L | 0-2 |
| Tyskland - DFB Pokal | 2021/10/27 16:30 | Bayer Leverkusen v Karlsruhe | L | 1-2 |
| Tyskland - Bundesliga | 2021/10/24 13:30 | FC Köln v Bayer Leverkusen | D | 2-2 |
| UEFA Europa League | 2021/10/21 16:45 | Real Betis v Bayer Leverkusen | D | 1-1 |
| Tyskland - Bundesliga | 2021/10/17 13:30 | Bayer Leverkusen v Bayern München | L | 1-5 |
| Tyskland - Bundesliga | 2021/10/03 17:30 | Arminia Bielefeld v Bayer Leverkusen | W | 0-4 |
| UEFA Europa League | 2021/09/30 19:00 | Celtic v Bayer Leverkusen | W | 0-4 |
| Tyskland - Bundesliga | 2021/09/25 13:30 | Bayer Leverkusen v Mainz | W | 1-0 |
Away History
| Spanien - La Liga | 2021/10/31 15:15 | Atletico Madrid v Real Betis | L | 3-0 |
| Spanien - La Liga | 2021/10/27 18:00 | Real Betis v Valencia | W | 4-1 |
| Spanien - La Liga | 2021/10/24 16:30 | Real Betis v Rayo Vallecano | W | 3-2 |
| UEFA Europa League | 2021/10/21 16:45 | Real Betis v Bayer Leverkusen | D | 1-1 |
| Spanien - La Liga | 2021/10/18 17:00 | CD Alaves v Real Betis | W | 0-1 |
| Spanien - La Liga | 2021/10/03 16:30 | Villarreal v Real Betis | L | 2-0 |
| UEFA Europa League | 2021/09/30 19:00 | Ferencváros v Real Betis | W | 1-3 |
| Spanien - La Liga | 2021/09/26 19:00 | Real Betis v Getafe | W | 2-0 |