[2] Real Betis 1-1 Bayer Leverkusen [1] 2021-10-21 16:45
Stadium: Benito Villamarin Round: 3
Referee: Bartosz Frankowski Home Manager: Manuel Pellegrini Away Manager: Gerardo Seoane
Home History
| Spanien - La Liga | 2021/10/18 17:00 | CD Alaves v Real Betis | W | 0-1 |
| Spanien - La Liga | 2021/10/03 16:30 | Villarreal v Real Betis | L | 2-0 |
| UEFA Europa League | 2021/09/30 19:00 | Ferencváros v Real Betis | W | 1-3 |
| Spanien - La Liga | 2021/09/26 19:00 | Real Betis v Getafe | W | 2-0 |
| Spanien - La Liga | 2021/09/23 17:30 | Osasuna v Real Betis | W | 1-3 |
| Spanien - La Liga | 2021/09/19 16:30 | Real Betis v Espanyol | D | 2-2 |
| UEFA Europa League | 2021/09/16 16:45 | Real Betis v Celtic | W | 4-3 |
| Spanien - La Liga | 2021/09/13 20:00 | Granada v Real Betis | W | 1-2 |
Away History
| Tyskland - Bundesliga | 2021/10/17 13:30 | Bayer Leverkusen v Bayern München | L | 1-5 |
| Tyskland - Bundesliga | 2021/10/03 17:30 | Arminia Bielefeld v Bayer Leverkusen | W | 0-4 |
| UEFA Europa League | 2021/09/30 19:00 | Celtic v Bayer Leverkusen | W | 0-4 |
| Tyskland - Bundesliga | 2021/09/25 13:30 | Bayer Leverkusen v Mainz | W | 1-0 |
| Tyskland - Bundesliga | 2021/09/19 13:30 | VfB Stuttgart v Bayer Leverkusen | W | 1-3 |
| UEFA Europa League | 2021/09/16 16:45 | Bayer Leverkusen v Ferencváros | W | 2-1 |
| Tyskland - Bundesliga | 2021/09/11 13:30 | Bayer Leverkusen v Borussia Dortmund | L | 3-4 |
| Tyskland - Bundesliga | 2021/08/28 13:30 | Augsburg v Bayer Leverkusen | W | 1-4 |