Stadium: Provost Umphrey Stadium Round: 1
Home Manager: Blane Morgan Away Manager: John Grass
| NCAAF | 2021/11/06 18:00 | Abilene Christian v Jacksonville State | W | 25-40 |
| NCAAF | 2021/10/30 18:00 | Central Arkansas v Jacksonville State | L | 38-14 |
| NCAAF | 2021/10/23 19:00 | Jacksonville State v Sam Houston State | L | 7-42 |
| NCAAF | 2021/10/09 20:00 | Stephen F. Austin v Jacksonville State | W | 24-28 |
| NCAAF | 2021/10/02 19:00 | Jacksonville State v Kennesaw State | L | 6-31 |
| NCAAF | 2021/09/25 20:00 | Tennessee Martin v Jacksonville State | L | 34-31 |
| NCAAF | 2021/09/18 23:00 | North Alabama v Jacksonville State | W | 24-27 |
| NCAAF | 2021/09/12 00:00 | Jacksonville State v Florida State | W | 20-17 |
| NCAAF | 2021/11/06 23:00 | Lamar v Tarleton State | L | 21-42 |
| NCAAF | 2021/10/30 18:00 | Lamar v Eastern Kentucky | L | 10-42 |
| NCAAF | 2021/10/23 23:00 | Central Arkansas v Lamar | L | 49-38 |
| NCAAF | 2021/10/16 20:00 | Lamar v Abilene Christian | L | 17-24 |
| NCAAF | 2021/10/09 19:00 | Lamar v Sam Houston State | L | 7-41 |
| NCAAF | 2021/09/25 23:00 | Abilene Christian v Lamar | L | 56-0 |
| NCAAF | 2021/09/18 20:00 | Lamar v Northern Colorado | W | 17-10 |
| NCAAF | 2021/09/11 22:00 | Lamar v Texas-San Antonio | L | 0-54 |