Stadium: Kessler Stadium Round: 1
Home Manager: Kevin Callahan Away Manager: Chris Willis
| NCAAF | 2021/10/23 19:00 | Charleston Southern v North Alabama | W | 22-45 |
| NCAAF | 2021/10/16 23:00 | Robert Morris v North Alabama | W | 31-42 |
| NCAAF | 2021/10/09 17:00 | North Alabama v North Carolina A&T | L | 34-38 |
| NCAAF | 2021/10/02 23:00 | Campbell v North Alabama | L | 48-31 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | L | 14-31 |
| NCAAF | 2021/09/18 23:00 | North Alabama v Jacksonville State | L | 24-27 |
| NCAAF | 2021/09/11 23:00 | Tennessee Chattanooga v North Alabama | L | 20-0 |
| NCAAF | 2021/09/04 23:00 | SE Louisiana v North Alabama | L | 49-28 |
| NCAAF | 2021/10/30 17:00 | Monmouth v North Carolina A&T | W | 35-16 |
| NCAAF | 2021/10/16 17:00 | Monmouth v Campbell | W | 34-17 |
| NCAAF | 2021/10/09 17:00 | Princeton v Monmouth | L | 31-28 |
| NCAAF | 2021/10/02 17:00 | Gardner Webb v Monmouth | W | 17-54 |
| NCAAF | 2021/09/25 17:00 | Holy Cross v Monmouth | L | 45-15 |
| NCAAF | 2021/09/18 22:00 | Monmouth v Charleston Southern | W | 41-14 |
| NCAAF | 2021/09/11 22:00 | Monmouth v Fordham | W | 26-23 |
| NCAAF | 2021/09/04 23:00 | Monmouth v Middle Tennessee St. | L | 15-50 |