Head to Head
| NFL - Førsæson | 2019/08/24 00:00 | BUF Bills v DET Lions | W | 24-20 |
| NFL | 2018/12/16 18:00 | DET Lions v BUF Bills | W | 13-14 |
| NFL - Førsæson | 2017/08/31 23:00 | BUF Bills v DET Lions | W | 27-17 |
| NFL - Førsæson | 2016/09/01 23:30 | DET Lions v BUF Bills | L | 31-0 |
| NFL | 2014/10/05 17:00 | DET Lions v BUF Bills | W | 14-17 |
Home History
| NFL | 2021/01/24 23:40 | BUF Bills v KC Chiefs | L | 24-38 |
| NFL | 2021/01/17 01:15 | BAL Ravens v BUF Bills | W | 3-17 |
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | W | 24-27 |
| NFL | 2021/01/03 18:00 | MIA Dolphins v BUF Bills | W | 26-56 |
| NFL | 2020/12/29 01:15 | BUF Bills v NE Patriots | W | 38-9 |
| NFL | 2020/12/19 21:30 | BUF Bills v DEN Broncos | W | 48-19 |
| NFL | 2020/12/14 01:20 | PIT Steelers v BUF Bills | W | 15-26 |
| NFL | 2020/12/08 01:15 | BUF Bills v SF 49ers | W | 34-24 |
Away History
| NFL | 2021/01/03 18:00 | MIN Vikings v DET Lions | L | 37-35 |
| NFL | 2020/12/26 18:00 | TB Buccaneers v DET Lions | L | 47-7 |
| NFL | 2020/12/20 18:00 | DET Lions v TEN Titans | L | 25-46 |
| NFL | 2020/12/13 21:25 | GB Packers v DET Lions | L | 31-24 |
| NFL | 2020/12/06 18:00 | DET Lions v CHI Bears | W | 34-30 |
| NFL | 2020/11/26 17:30 | HOU Texans v DET Lions | L | 41-25 |
| NFL | 2020/11/22 18:00 | DET Lions v CAR Panthers | L | 0-20 |
| NFL | 2020/11/15 18:00 | WAS Commanders v DET Lions | W | 27-30 |