[14] John Isner 6-7,7-6,6-7 Reilly Opelka [57] 2019-07-24 23:00
Stadium: Stadium Court Round: 26 Ground: Hardcourt outdoor
Head to Head
| ATP - New York | 2019/02/17 00:00 | John Isner v Reilly Opelka | 7-6,6-7,6-7 |
| Australian Open | 2019/01/14 02:55 | Reilly Opelka v John Isner | 7-6,7-6,6-7,7-6 |
Home History
| ATP - Newport | 2019/07/21 18:00 | John Isner v Alexander Bublik | 7-6,6-3 |
| ATP - Newport | 2019/07/20 19:25 | John Isner v Ugo Humbert | 6-7,7-6,6-3 |
| ATP - Newport | 2019/07/19 18:35 | John Isner v Matthew Ebden | 4-6,6-3,6-4 |
| ATP - Newport | 2019/07/17 18:40 | John Isner v Kamil Majchrzak | 6-4,6-7,6-3 |
| Wimbledon | 2019/07/04 12:00 | Mikhail Kukushkin v John Isner | 6-4,6-7,4-6,6-1,6-4 |
| Wimbledon | 2019/07/02 16:55 | Casper Ruud v John Isner | 3-6,4-6,6-7 |
| ATP - Miami | 2019/03/31 17:00 | John Isner v Roger Federer | 1-6,4-6 |
| ATP - Miami | 2019/03/29 17:00 | John Isner v Felix Auger Aliassime | 7-6,7-6 |
Away History
| ATP - Atlanta | 2019/07/23 18:25 | Reilly Opelka v Alexander Bublik | 6-3,7-6 |
| Wimbledon | 2019/07/05 10:00 | Reilly Opelka v Milos Raonic | 6-7,2-6,1-6 |
| Wimbledon | 2019/07/03 10:00 | Stan Wawrinka v Reilly Opelka | 5-7,6-3,6-4,4-6,6-8 |
| Wimbledon | 2019/07/01 10:00 | Cedrik-Marcel Stebe v Reilly Opelka | 3-6,6-7,1-6 |
| ATP - Eastbourne | 2019/06/24 14:00 | Steve Johnson v Reilly Opelka | 7-6,6-3 |
| French Open | 2019/05/27 10:40 | Reilly Opelka v Cristian Garin | 6-7,5-7,6-7 |
| ATP - Lyon | 2019/05/21 09:00 | Corentin Moutet v Reilly Opelka | 6-3,2-6,7-6 |
| ATP - Rom | 2019/05/12 15:05 | Benoit Paire v Reilly Opelka | 5-7,6-2,7-6 |