The First Women's Basketball League of Serbia (Serbian: Прва женска лига Србије, romanized: Prva ženska liga Srbije; abbr. ПЖЛС or PŽLS), is a top-tier women's professional basketball league in Serbia. Founded in 2006, it is run by the Basketball Federation of Serbia (KSS).

The league is divided into two parts. The first part of the play all the clubs who have won a place in it. In the second part, called the playoffs, they play eight first clubs from the first division. Play starts from the quarter-final of the series, where the winner is decided in two games, the same system is in the semifinals, while the final series game in three wins. Clubs from Serbia who play in the Adriatic league, play along with the domestic the League.

History